Education
- Ph.d. In Chemistry, Technical University Freiberg - Freiberg, Germany, 2012
- M.sc. (Dipl.-chem.) In Chemistry, graduated with honors, Technical University Freiberg - Freiberg, Germany, 2008
Areas of Interest
Cardiovascular active peptides and GPCR receptor signaling - Viral protease inhibitors - Nature-inspired supramolecular inclusion hosts
Biography
Joined Barry: January 2021.
Courses
- CHE 343, CHE 343L Organic Chemistry with Lab, I
- CHE 344, CHE 344L Organic Chemistry with Lab, II
- CHE 352, CHE 352L Biochemistry I with Lab
- CHE 395, CHE 495 Research
Research Interests
- Cardiovascular active peptides and GPCR receptor signaling
- Viral protease inhibitors
- Nature-inspired supramolecular inclusion hosts
Selected Publications
- Fischer, C.; Lamer, T.; Fernandez, K.; Gheblawi, M.; Wang, W.; Pascoe, C.; Lambkin, G.; Iturrioz, X.; Llorens-Cortes, C.; Oudit, G.Y.; Vederas, J.C. Optimizing PEG-extended apelin analogues as cardioprotective drug leads. Importance of the KFRR motif and aromatic head group for improved physiological activity. J. Med. Chem., 63, 12073-12082, 2020
- Vuong, W.; Khan, M.B.; Fischer, C.; Arutyunova, E.; Lamer, T.; Shields, J.; Bandi, H.; McKay, R.T.; van Belkum, M.J.; Joyce, M.; Young, H.S.; Tyrrell, L.; Vederas, J.C.; Lemieux, M. J. Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication, Nature Commun., 11, 4282, 2020
- Fischer, C. A patent review of apelin receptor modulators (2014-2019), Expert Opin. Ther. Pat., 30, 251-261, 2020
- Masoud, A.G.T.; Lin, J.X.; Farhan, M.A.; Fischer, C.; Zhu, L. F.; Anderson, C. C.; Sis, B.; Kassiri, Z.; Moore, R. B.; Kim, D.; Vederas, J. C.; Adam, B. A.; Oudit, G. Y.; Murray, A. G. Apelin directs endothelial cell differentiation and vascular repair following immune-mediated injury, J. Clin. Invest., 130, 94-107, 2020
Selected Conference Presentations
- Apelin analogues as novel cardioprotective drugs, 102nd Canadian Chemistry Conference and Exhibition, June 2019, Quebéc, Canada
- PEGylated apelin analogues as cardiovascular active drugs, 101st Canadian Chemistry Conference and Exhibition, May 2018, Edmonton, Canada
- Apelin as key peptide for heart disease treatment, 1st RSC Anglo-Nordic Medical Chemistry Symposium, June 2017, Snekkersten Conference Center, Helsingør, Denmark
- Engineered apelin and natriuretic peptides as potent therapeutics for the treatment of cardiovascular diseases. Invited talk, June 2017, University of Lincoln, Lincoln, UK
- Apelin as key peptide for heart disease treatment. 34th European Peptide Symposium, September 2016, University of Leipzig, Leipzig, Germany
- Laterally modified calix[4]arenes as potential sensor materials. 20th Junior Research-Symposium in Bioorganic chemistry, September 2011, KIT Karlsruhe, Karlsruhe, Germany
Honors/Awards
- 2016-2018 Postdoctoral Fellowship, Alberta Innovates Health Solutions
- 2014-2015 Postdoctoral Fellowship, Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)
- 2008 M.Sc. thesis award, Agricola Medal and Price for best MSc thesis in 2008, University Freiberg, Germany
Professional Membership
- ACS – American Chemical Society, 2021-present
- CSC – Canadian Society of Chemistry, 2018-present
- GDCh – German Chemical Society, 2008-present
Contact Information
- Office: Wiegand 128A
- Telephone: 305-899-3430
- Fax: 305-899-3479
- E-mail: cfischer@barry.edu